Concepedia

Efficient, direct α-methylenation of carbonyls mediated by diisopropylammonium trifluoroacetate

Alejandro Bugarin, K. Jones, Brian T. Connell

Chemical Communications · 2010 · 84 citations · 35 references

DOI

Concepts

Abstract

A very efficient method for the direct α-methylenation of carbonyl compounds, with yields up to 99%, utilizing paraformaldehyde, diisopropylammonium trifluoroacetate, and catalytic acid or base, is presented.

References

35

Isolation and structure of brevetoxin B from the "red tide" dinoflagellate Ptychodiscus brevis (Gymnodinium breve)

Yong-Yeng Lin, Martin Risk, Sammy M. Ray et al. · Journal of the American Chemical Society · 1981 · 541 citations

, , +23

Advances in the Baylis–Hillman reaction-assisted synthesis of cyclic frameworks

V. P. Singh, Sanjay Batra · Tetrahedron · 2008 · 513 citations

, ,

The First General Enantioselective Catalytic Diels−Alder Reaction with Simple α,β-Unsaturated Ketones

Alan B. Northrup, David W. C. MacMillan · Journal of the American Chemical Society · 2002 · 449 citations

, , +13

Metal‐Free, Organocatalytic Asymmetric Transfer Hydrogenation of α,β‐Unsaturated Aldehydes

Jung Woon Yang, Maria T. Hechavarria Fonseca, Nicola Vignola et al. · Angewandte Chemie International Edition · 2004 · 340 citations · Full text

Aza‐Baylis–Hillman Reactions and Their Synthetic Applications

Yong‐Ling Shi, Min Shi · European Journal of Organic Chemistry · 2007 · 241 citations

, , +8