Journal of the Chemical Society Perkin Transactions 1 · 1981 · 37 citations · 0 references
Position 3Bioorganic ChemistryLithium SaltsEngineeringMolecular BiologyOrganic ChemistryAntimicrobial ChemotherapyChemistryChemical BiologyNew RouteDrug ResistanceChemical EngineeringAerial OxidationOrganometallic CatalysisMolecular DiversityBioprospectingNatural SciencesMicrobiologySynthetic Chemistry
The lithium salts derived from position 3 of phthalides react with arynes to form adducts, which, upon aerial oxidation, produce anthraquinones in moderate to good yields. Substituted phthalides and arynes also participate in this general reaction. The addition to unsymmetrically substituted arynes shows regioselectivity, whilst the availability of a new general route to phthalides extends the scope of this reaction.