Concepedia

The Effect of ABCG2 and ABCC4 on the Pharmacokinetics of Methotrexate in the Brain

Ramola Sane, Shu-Pei Wu, Rong Zhang, James M. Gallo

Drug Metabolism and Disposition · 2014 · 29 citations · 32 references

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References

32

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

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Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors

Yasuo Uchida, Sumio Ohtsuki, Yuki Katsukura et al. · Journal of Neurochemistry · 2011 · 909 citations

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The MRP4/ABCC4 Gene Encodes a Novel Apical Organic Anion Transporter in Human Kidney Proximal Tubules

R.A.M.H. van Aubel, Pascal H. E. Smeets, Janny G.P. Peters et al. · Journal of the American Society of Nephrology · 2002 · 500 citations

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Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

Markos Leggas, Masashi Adachi, George L. Scheffer et al. · Molecular and Cellular Biology · 2004 · 414 citations · Full text

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Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

Zhe‐Sheng Chen, Kun Hee Lee, Susan Walther et al. · PubMed · 2002 · 319 citations

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