What is Amphidinolide V? Report on a Likely Conquest

Abstract

The awesome power of metathesis is reflected in the synthesis of the proposed structure of the cytotoxic natural product amphidinolide V, as well as of all other stereomers containing a trans-epoxide unit. It can be concluded from the comprehensive data set obtained that the 8S,9R,10R,13S-configured compound 1 most likely represents amphidinolide V, even though a single resonance in the 1H NMR spectrum deviates from the reported value.