Levels of circulating tumor necrosis factor α and interleukin‐6 in patients with rheumatoid arthritis. relationship to serum levels of hyaluronan and antigenic keratan sulfate

Abstract

These in vivo data support in vitro studies which have shown that TNF alpha is a potent stimulator of HA synthesis by synovial lining cells. The results strengthen the contention that serum HA may be a unique marker of synovial involvement and inflammation, rather than of only inflammation, in RA.