Conformational Switching of G‐Quadruplex DNA by Photoregulation

Abstract

Bend and stretch…︁ bend and stretch…︁ An azobenzene derivative was used to induce reversible stretching and folding of G-quadruplex DNA upon photoirradiation (see picture). The G quadruplex formed in the presence of the trans isomer was dissociated by irradiation with UV light, and the resulting open oligomer was refolded into a G quadruplex under visible light. This nanodevice thus converts light directly into mechanical work. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.