Angewandte Chemie International Edition · 1999 · 337 citations · 0 references
Bioorganic ChemistryEngineeringOrganic ChemistryChemistryPseudo-enantiomeric Products 2Chemical EngineeringAnalytical ChemistryStereoselective SynthesisProchiral SubstratesBiochemistryBiocatalysisCatalysisNatural Product SynthesisAsymmetric CatalysisRacemic CompoundsEnantioselective SynthesisCatalytic SynthesisNatural SciencesMass SpectrometryHigh-throughput ScreeningDrug Analysis
About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled substrates. The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo-enantiomeric products 2 and 3.