Concepedia

Growth Differentiation Factor 15 (GDF-15) in Patients Admitted for Acute Heart Failure: Results from the RELAX-AHF Study

Gad Cotter, Adriaan A. Voors, Margaret F. Prescott, G. Michael Felker, Gerasimos Filippatos, Barry Greenberg, Peter S. Pang, Piotr Ponikowski, Olga Milo, Tsushung A. Hua,

European Journal of Heart Failure · 2015 · 104 citations · 18 references

DOIFull text

Open access

Abstract

In AHF patients enrolled in the RELAX-AHF study, increases in GDF-15 levels, but not baseline measurements, were associated with a greater likelihood of adverse outcomes. Serelaxin administration was associated with greater decreases in GDF-15 compared with placebo.

References

18

The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations.

Reuben M. Baron, David A. Kenny · Journal of Personality and Social Psychology · 1986 · 71.8K citations

, , +14

The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations.

Reuben M. Baron, David A. Kenny · Journal of Personality and Social Psychology · 1986 · 69.4K citations

, , +8

A comparison of methods to test mediation and other intervening variable effects.

David P. MacKinnon, Chondra M. Lockwood, Jeanne M. Hoffman et al. · Psychological Methods · 2002 · 9K citations

, , +14

A DISTRIBUTION-FREE <i>k</i>-SAMPLE TEST AGAINST ORDERED ALTERNATIVES

A. R. Jonckheere · Biometrika · 1954 · 1.5K citations

, , +15

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

John R. Teerlink, Gad Cotter, Beth A. Davison et al. · The Lancet · 2012 · 896 citations

, , +10