Simple and Efficient Method for Acetylation of Alcohols, Phenols, Amines, and Thiols Using Anhydrous NiCl₂ Under Solvent-Free Conditions

Abstract

Abstract Solvent-free acetylation of alcohols, phenols, amines, and thiols with acetic anhydride (Ac2O) in the presence of 0.1 mol% (13 mg) anhydrous NiCl2, an inexpensive and easily available catalyst, is described. Excellent yields, short reaction time, and mild reaction conditions are important features of this method.