Publication | Closed Access
Asymmetric Hydrogenation of Quinolines Catalyzed by Iridium Complexes of Monodentate BINOL‐Derived Phosphoramidites
143
Citations
83
References
2008
Year
EngineeringTri‐ Ortho ‐TolylphosphineMonodentate Binol‐derived PhosphoramiditesOrganic ChemistryChemistryChemical EngineeringMixed ComplexesOrganometallic CatalysisHomogeneous CatalysisInorganic ChemistryIridium ComplexesDiversity-oriented SynthesisIridium‐catalyzed Asymmetric HydrogenationCatalysisAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringAsymmetric HydrogenationNatural SciencesMolecular Catalysis
Abstract The monodentate BINOL‐derived phosphoramidite PipPhos is used as ligand for the iridium‐catalyzed asymmetric hydrogenation of 2‐ and 2,6‐substituted quinolines. If tri‐ ortho ‐tolylphosphine and/or chloride salts are used as additives enantioselectivities are strongly enhanced up to 89%. NMR indicates that no mixed complexes are formed upon addition of tri‐ ortho ‐tolylphosphine.
| Year | Citations | |
|---|---|---|
Page 1
Page 1