Copper‐Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols

Abstract

Tandem jump: A novel copper-catalyzed tandem trifluoromethylation/semipinacol rearrangement reaction of allylic alcohols has been achieved under mild conditions. This reaction is valuable for the difunctionalization of alkenes through simultaneous construction of a CCF3 bond and a quaternary carbon center, and could provide a straightforward strategy for the preparation of α-quaternary β-trifluoromethyl ketone derivatives. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.