Catalytic <i>Z</i>‐Selective Cross‐Metathesis with Secondary Silyl‐ and Benzyl‐Protected Allylic Ethers: Mechanistic Aspects and Applications to Natural Product Synthesis

Abstract

Get me a­ Z (olefin): Efficient catalytic cross-metathesis reactions that afford Z-disubstituted allylic silyl or benzyl ethers are reported (see scheme, MAP=monoalkoxide pyrrolide). The approach, in combination with catalytic cross-coupling, provides a general entry to otherwise difficult-to-access alkyne-containing Z olefins.