Ethanol Suppresses LPS‐induced Toll‐like Receptor 4 Clustering, Reorganization of the Actin Cytoskeleton, and Associated TNF‐<i>α</i> Production

Abstract

These data confirm our previous observations, suggest a novel mechanism of EtOH action that involves interference with receptor clustering, and indicate a potential role of actin filaments in the formation of receptor patches, subsequent activation of macrophages by LPS, and production of TNF-alpha.