Serologic Response to Varicella-Zoster Membrane Antigens Measured by Indirect Immunofluorescence

Abstract

A technique was developed for the detection by immunofluorescence of antigen on the membrane or surface of cells infected with varicella-zoster virus. The detection of antibody to this membrane antigen has been used successfully to confirm the clinical diagnosis of varicella-zoster infection. Its particular advantage over existing methods, however, is its usefulness in determination of susceptibility to. varicella. The method described is rapid, sensitive, specific, and easy to perform.