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EVIDENCE FOR THE REGULATION OF 3β-HYDROXYSTEROID DEHYDROGENASE MESSENGER RNA BY HUMAN CHORIONIC GONADOTROPHIN IN LUTEINIZED PORCINE GRANULOSA CELLS
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1990
Year
GynecologyFemale Reproductive FunctionReproductive BiologyMessenger RnaBeta-ohsd GeneReproductive PhysiologyReproductive EndocrinologyPublic HealthSteroid MetabolismHormonal ReceptorEndocrinologyGene ExpressionCell BiologyLuteinized TissueOvarian HormoneDevelopmental BiologyReceptor BiologyMetabolismMedicineReproductive HormoneGonadotropin Biology
The effects of hCG on the abundance of messenger RNA for the steroidogenic enzyme 3 beta-hydroxysteroid dehydrogenase (3 beta-OHSD) were studied in luteinized porcine granulosa cells. There were dose-dependent increases in the mRNA for this enzyme after 8 h incubation with hCG or dibutyryl cAMP. The results suggest that LH-like hormones regulate the expression of the 3 beta-OHSD gene in luteinized tissue, and this genomic regulation is a component of the luteotrophic regulation of steroidogenesis in the ovary.