Gene Expression of Brain Natriuretic Peptide in Isolated Atrial and Ventricular Human Myocardium

Abstract

Cardiac hypertrophy can be induced in isolated human atrial and left ventricular intact myocardium by Ang II and diastolic overstretch but not by isometric afterload. The fact that the induction of cardiac growth is inhibited by the blockade of Ang II subtype 1 receptors is of scientific and clinical importance.