Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase

Abstract

The writing's on the (cell) wall: A series of Lipid II analogues with modifications to the peptide moiety were evaluated as substrates of bacterial transglycosylase. The first two positions on the peptide, D-lactate and L-alanine (see scheme), especially their methyl groups, were found to be essential for substrate-binding activity, an important discovery for the design of antibiotics to inhibit cell-wall biosynthesis. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.