Microwave assisted efficient one-pot synthesis of 3,5,6-trisubstituted-1,2,4-triazines from fatty acid hydrazides under solvent-free conditions and their antimicrobial activity

Abstract

Rapid and efficient solvent-free synthesis of 3,5,6-trisubstituted-1,2,4-triazines from fatty acid hydrazides under microwave irradiation is described. The one-pot synthesis on solid inorganic support provides the products in good yields. The newly synthesized compounds are screened for antimicrobial activity. The structural features of the synthesized 1,2,4-triazines were characterized by IR, 1 H NMR, 13 C NMR, mass and elemental analysis.