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A new enantioselective synthesis of trans 2,5-disubstituted pyrrolidine derivatives by radical cyclisation
11
Citations
11
References
1994
Year
Radical CyclisationNew Enantioselective SynthesisDiversity Oriented SynthesisDerivativesEngineeringHeterocyclicNatural SciencesDiversity-oriented SynthesisOrganic ChemistryC2-symmetrical 2,5-Dibenzyloxypyrrolidin-2-oneStereoselective SynthesisChemistryPharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringIntramolecular Radical Cyclization
A new and highly enantioselective synthesis of trans 5-substituted 2-hydroxymethylpyrrolidine derivatives is achieved by intramolecular radical cyclization at the 4-position of Δ4,5-oxazolidin-2-one, which leads to C2-symmetrical 2,5-dibenzyloxypyrrolidin-2-one.
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