Deletion/Insertion Polymorphism of the Angiotensin‐Converting Enzyme Gene and White Matter Hyperintensities in Dementia: A Pilot Study

Abstract

The results support previous observations that genetic factors influence the development of WMHs in dementia. The involvement of the ACE D/I polymorphism in the pathogenesis of DWMHs in dementia (AD and VaD), by a mechanism that is independent of its association with cardiovascular risk factors, should be confirmed in a large population-based sample.