Suppression of Established Friend Virus Leukemia by Statolon. IV. Role of Humoral Antibody in the Development of a Dormant Infection<xref ref-type="fn" rid="FN2">2</xref>

Abstract

Statolon suppressed established Friend virus (FV) leukemia in DBA/2 mice by stimulating an immune response to FV and FV-transformed cells. Mice in which the FV infection was completely suppressed by statolon (FV carriers) produced more FV-neutralizing, FV-cell-binding, in vitro FV-cytotoxic, and in vivo anti-FV-leukemic antibody than mice which rapidly developed leukemia despite treatment with statolon. As FV-carrier mice aged, antibody levels declined and FV emerged from its dormant state to produce overt leukemia.