Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Wei Xie, Jeffrey G. Chipman, Donald Robertson et al. · Proceedings of the National Academy of Sciences · 1991 · 1.7K citations · Full text

Src-transformed Cells, Mrna Splicing, Rna Splicing +23

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Jane A. Mitchell, Pravit Akarasereenont, Christoph Thiemermann et al. · Proceedings of the National Academy of Sciences · 1993 · 1.7K citations · Full text

Intact Cells, Immunology, Pharmacotherapy +17

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

Karen Seibert, Y Zhang, K. Leahy et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations · Full text

Pain Medicine, Immunology, Molecular Pain +22

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Jaime L. Masferrer, Ben S. Zweifel, Pamela T. Manning et al. · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations · Full text

Inflammation, Molecular Pharmacology, Selective Inhibition +14

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

Elizabeth A. Meade, William L. Smith, David L. DeWitt · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

Lipid Peroxidation, Pharmacotherapy, Common Nsaids +19