Gene Transfer of Endothelial Nitric Oxide Synthase Partially Restores Nitric Oxide Synthesis and Erectile Function in Streptozotocin Diabetic Rats

Abstract

Adenoviral gene transfer of eNOS significantly increased peak and total intracavernous pressure to cavernous nerve stimulation in streptozotocin diabetic rats to a value similar to the response observed in control rats. Our results suggest that eNOS contributes significantly to the physiology of penile erection. These data demonstrate that in vivo adenoviral gene transfer of eNOS can physiologically improve erectile function in the streptozotocin diabetic rat.