Effect of Glucocorticoid on Upregulation of Histamine H₁Receptor mRNA in Nasal Mucosa of Rats Sensitized by Exposure to Toluene Diisocyanate

Abstract

As shown in TDI-sensitized rats, our findings suggest that the upregulation of H1R in the nasal mucosa is one of the mechanisms responsible for nasal hypersensitivity behavior and nasal hypersensitivity to histamine and that the therapeutic effects of dexamethasone are, in part, due to its inhibitory action on the upregulation of H1R.