Association of High-Level <i>MRP1</i> Expression With Poor Clinical Outcome in a Large Prospective Study of Primary Neuroblastoma

Abstract

The results of this prospective study confirm our earlier findings and support a clinically relevant role for MRP1 gene expression in neuroblastoma. These findings have implications for the biology, prognosis, and treatment of this disease and provide evidence that MRP1 is a bone fide molecular target for reversing chemotherapy resistance in aggressive drug-refractory neuroblastoma.