Traceless Linkers-Only Disappearing Links in Solid-Phase Organic Synthesis?

Abstract

Traceless linkers, which enable the attachment of arenes and alkanes to a polymeric support, have received increased attention in recent years. These anchoring groups allow chemical transformations on the polymer-bound molecules, which can be cleaved from the resin leaving no residual functionality to bias the library. Various approaches based on different Group 14 to Group 16 heteroatoms have been developed in the past and used in new syntheses of diverse compound libraries.