Significant Decrease in Nelfinavir Systemic Exposure After Omeprazole Coadministration in Healthy Subjects

Abstract

The observed reduction in the systemic exposure to both nelfinavir and its active metabolite M8 after coadministration with omeprazole could result in loss of virologic control and potential emergence of drug resistance. Hence, omeprazole should not be coadministered to patients taking nelfinavir.