Photophobia in migraine: an interictal PET study of cortical hyperexcitability and its modulation by pain

Abstract

The study shows the lack of habituation and/or cortical hyperexcitability to light in migraineurs. Moreover, the activation by light of several visual cortex areas (including the primary visual cortex) was potentiated by trigeminal pain, demonstrating multisensory integration in these areas.