Delayed Whole-Body Cooling to 33 or 35°C and the Development of Impaired Energy Generation Consequential to Transient Cerebral Hypoxia-Ischemia in the Newborn Piglet

Abstract

Whole-body hypothermia for 24 hours at either 35 or 33 degrees C, commenced 2 hours after resuscitation, prolonged the NTP/EPP latent phase and reduced the overall secondary falls in mean PCr/Pi and NTP/EPP during 48 hours after HI. Reducing the temperature from 35 to 33 degrees C neither increased mean PCr/Pi and NTP/EPP nor further lengthened the latent phase.