Protection of Endothelial Survival by Peroxisome Proliferator-Activated Receptor-δ Mediated 14-3-3 Upregulation

Abstract

PGI2 protects ECs from H2O2-induced apoptosis by inducing PPARdelta binding to 14-3-3alpha promoter, thereby upregulating 14-3-3alpha protein expression. Elevated 14-3-3alpha augments Bad sequestration and prevents Bad-triggered apoptosis.