Slc26a3 deficiency is associated with loss of colonic <scp>HCO</scp>₃⁻ secretion, absence of a firm mucus layer and barrier impairment in mice

Abstract

Deletion of DRA results in severely reduced colonic HCO3 (-) secretory rate, a loss of colonic fluid absorption, a lack of a firmly adherent mucus layer and a severely reduced colonic mucosal resistance to DSS damage. These data provide potential pathophysiological explanations for the increased susceptibility of CLD patients to intestinal inflammation.