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Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-κB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia

Bbb PermeabilityImmunologyImmune RegulationOxidative StressNeuroinflammationInflammationDisease PhysiologyEndothelial Cell FunctionNeuroimmunologyCell SignalingMolecular SignalingVascular BiologyNeuroprotectionImmune FunctionFocal IschemiaPharmacologyCell BiologySignal TransductionEndothelial DysfunctionMedicineCell Development