Water‐Compatible Iminium Activation: Organocatalytic Michael Reactions of Carbon‐Centered Nucleophiles with Enals

Abstract

A pool of water-compatible catalysts, namely the chiral prolinol-based catalysts 1, has been developed for highly enantioselective CC bond-forming Michael reactions in water (see scheme). The synthesis of (S)-Rolipram, a type IV phosphodiesterase inhibitor, was also demonstrated. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z703261_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.