Amide‐to‐Ester Substitution in Coiled Coils: The Effect of Removing Hydrogen Bonds on Protein Structure

Abstract

The latest twist: The effect of backbone H-bonding on the stability of proteins was studied by experimental techniques and molecular dynamics simulation. The structure of the coiled-coil model peptide examined (see picture) is affected by interactions in the solvent-exposed regions as well as by interhelical hydrophobic interactions.