Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities

Abstract

Purity check: The self-assembly of magnetic nanoparticle sensors in the presence of stereoselective antibodies causes a decrease in the T2 relaxation time of surrounding protons. The introduction of enantiomeric impurities disrupts the antibody/magnetic-sensor binding and increases the T2 relaxation time, which can be monitored by magnetic resonance imaging (see picture).