Safety, tolerability and pharmacokinetics of escalating doses of NXY-059 in healthy young and elderly subjects

Abstract

NXY-059 was well tolerated at all plasma concentrations tested in both the young and elderly subjects, and no safety concerns were raised. Linear pharmacokinetics were observed following 8-h and 72-h infusions of NXY-059 at doses resulting in an average Cu(ss) in the 52-317 micromol/L range.