Concepedia

Gestational ethanol exposure disrupts the expression of FGF8 and Sonic hedgehog during limb patterning

Kimberly Chrisman, R.M. Kenney, Jeremy Comin, Tanya Thal, Lawrence Suchocki, Y. Gloria Yueh, David P. Gardner

Birth Defects Research Part A Clinical and Molecular Teratology · 2004 · 48 citations · 35 references

Abstract

We propose a model where ethanol disrupts the AER/ZPA positive feedback loop to induce postaxial malformations. Preaxial malformations seen at higher ethanol dosage suggest FGF8 as a critical target of ethanol in producing limb defects.

References

35

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chin Chiang, Ying Litingtung, Eric Lee et al. · Nature · 1996 · 3.1K citations

Biology, Knockout Mouse, Developmental Biology +6

RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY

KennethL. Jones, DavidW. Smith · The Lancet · 1973 · 2.8K citations

Prenatal Development, Early Childhood Development, Pediatrics +6

Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome

Chrysanthy Ikonomidou, Petra Bittigau, Masahiko Ishimaru et al. · Science · 2000 · 1.4K citations

Brain Development, Deleterious Effects, Glutamate Receptors +17

The mouse <i>Fgf8</i> gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

Philip H. Crossley, Gail R. Martin · Development · 1995 · 1.2K citations

SALMONELLAS IN MEAT.

L Wickstrom, K Pettersson · PubMed · 1964 · 1.2K citations

Foodborne Pathogens, Pathogenesis, Foodborne Illness +10