Bicyclization of Isocyanides: A Synthetic Strategy for Fused Pyrroles

Abstract

Abstract On the isocyanide carbon atom, two CC sigma bonds are formed in the bicyclization reaction of the readily available acyclic substrates with tosylmethyl isocyanides. The reaction can proceed under extremely mild and metal‐free conditions to give the products in high to excellent yields. The powerful potential of this strategy deserves attention because it is a new paradigm for trapping of the incipient imidoyl anion, by a carbon electrophile instead of a proton.