A Facile Construction of 6‐(Arylmethyl)imidazo[1,2‐<i>a</i>]pyrimidin‐7‐ylamines from Allylamines Derived from Baylis–Hillman Adducts

Abstract

Abstract A facile and convenient synthesis of substituted imidazo[1,2‐ a ]pyrimidin‐7‐ylamines from the allylamine derivatives afforded by the Baylis–Hillman acetates of substituted benzaldehydes and heterocyclic aldehydes by treatment with cyanamide is described. Interestingly, the allylamines afforded by heterocyclic aldehydes, which undergo fast Baylis–Hillman reaction, were discovered to undergo a one‐pot reaction, whereas allylamines derived from all other aldehydes reacted by a two‐step procedure.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)