Concepedia

Final results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial

Henricus J. Duckers, Jaco H. Houtgraaf, Christoph Hehrlein, Joachim Schofer, Johannes Waltenberger, Anthony Gershlick, Jozef Bartúnek, Christoph Nienaber, Carlos Macaya, Nicholas S. Peters,

EuroIntervention · 2011 · 108 citations · 12 references

DOIFull text

Open access

Abstract

These data indicate that implantation of myoblasts in patients with HF is feasible, appears to be safe and may provide symptomatic relief, though no significant effect was detected on global LVEF.

References

12

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult

Sharon A. Hunt, William T. Abraham, Marshall H. Chin et al. · Circulation · 2005 · 2.3K citations · Full text

Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction

Philippe Menasché, Albert Hagège, Jean‐Thomas Vilquin et al. · Journal of the American College of Cardiology · 2003 · 1.1K citations

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The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial

Philippe Menasché, Ottavio Alfieri, Stefan Janssens et al. · Circulation · 2008 · 938 citations

Catheter-Based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure

Pieter C. Smits, Robert‐Jan van Geuns, Don Poldermans et al. · Journal of the American College of Cardiology · 2003 · 535 citations

, , +12

One-Year Follow-Up of Feasibility and Safety of the First U.S., Randomized, Controlled Study Using 3-Dimensional Guided Catheter-Based Delivery of Autologous Skeletal Myoblasts for Ischemic Cardiomyopathy (CAuSMIC Study)

Nabil Dib, Jonathan Dinsmore, Zaki Lababidi et al. · JACC: Cardiovascular Interventions · 2009 · 123 citations

, , +7