Concepedia

Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis

Margreke J. E. Brill, Aletta P. I. Houwink, Stephan Schmidt, E.P.A. van Dongen, Eric J. Hazebroek, Bert van Ramshorst, Vera H.M. Deneer, Johan W. Mouton, Catherijne A. J. Knibbe

Journal of Antimicrobial Chemotherapy · 2013 · 130 citations · 22 references

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Abstract

This study shows that cefazolin tissue distribution is lower in morbidly obese patients and reduces with increasing body weight, and that dose adjustments are required in this patient group.

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