One‐Step Homogeneous DNA Assay with Single‐Nanoparticle Detection

Abstract

Staying single: A DNA hybridization assay employs gold-nanoparticle (AuNP) probes and single-particle inductively coupled plasma spectrometry (ICP-MS; see picture). The degree of aggregation of AuNPs is characterized by simultaneous measurement of decreased concentrations of the AuNP population and increased individual sizes.