Polycondensation of amino acids by means of diphenyl phosphite in the presence of pyridine

Abstract

Abstract Linear polypeptides of high molecular weights were obtained by the direct polycondensation reactions of free α‐amino acids and dipeptides with diphenyl phosphite ( 1 ) in pyridine. The reaction was affected by solvent, tertiary amine, amino acid concentration, and temperature. The copolycondensation was also carried out using various couples of optically active or inactive amino acids. The compositions of the copolypeptides were compared with those by the NCA method.