African Journal of Pharmacy and Pharmacology · 2009 · 65 citations · 5 references
PharmacyMedicinal ChemistryPharmacologyAntimicrobial PharmacologyDrug DiscoveryStructure-activity RelationshipsAntibacterial AgentsAntibacterial PharmacologyBioactive Natural ProductsMedicinal Plant KnowledgeMedicinal PlantsNatural Product Drug DiscoveryAlkaloid ProfilesBioactive Plant CompoundsEscherichia ColiMedicinal Aromatic PlantsMedicinal HerbsMedicinal Plant ResourcesPharmacological ScreeningPlant Alkaloids
A new antibacterial agent 51,71 dimethyl 61– hydroxy 31, phenyl 3 ii - amine i¢ - yne sitosterol 1 has been isolated from Datura metel leaves. The structure of 1 was established using 13C, 1H NMR, IR and MS spectroscopic data. Compound 1 displayed antibacterial activity against Staphylococcus aureus,Pseudomonas aeruginosa, Proteus mirabis, Solmonella typhi, Bacillus subtilisand Klebsiella pneumonia but could not inhibit Escherichia coli. This result supported the use of Datura metel in phytomedicine for the treatment of asthma, cough, burns and healing of wounds in Nigeria. Key words: Datura metel, sterol alkaloid, antibacterial agent, phytomedicine.
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