Creating Chemical Diversity in Indole Compounds by Merging Au and Ru Catalysis

Abstract

Abstract Sequential dual‐metal catalyzed reactions are successfully applied to create chemical diversity in indole polycyclic alkaloids. Gold‐catalyzed intramolecular allylic alkylation of indoles with alcohols, followed by Ru‐assisted ring‐closing metathesis opens up access to a large variety of functionalized tetrahydrocarbazoles and tetrahydro‐β‐carbolines in a straightforward manner. The gold‐catalyzed alkylation allows complex molecular architectures to be realized in a highly regio‐ and stereocontrolled manner.