The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome

Abstract

The presence of long SHBG(TAAAA)n alleles is associated with increased risk for PCOS and in combination with short AR(CAG)n alleles may influence the hyperandrogenic phenotype of PCOS. This combined genotype may contribute to 'fetal programming' of PCOS.