Cyclic <i>iso</i>DGR Peptidomimetics as Low‐Nanomolar α_vβ₃ Integrin Ligands

Abstract

A perfect fit: Shown here is the docking best pose of a low-nanomolar αvβ3 integrin ligand cyclo[DKP-isoDGR] (atom color tube representation; see figure) into the receptor binding pocket, overlaid on the bound conformation of Cilengitide (green tube representation). The extended isoDGR conformation permits all the important interactions with the extracellular domain of the αvβ3 integrin. The metal ion in the MIDAS region is represented by a magenta sphere. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.