Photodynamic oxidation of <i>Escherichia coli</i> membrane phospholipids: new insights based on lipidomics

Abstract

Membrane phospholipids of E. coli are molecular targets of the photodynamic effect induced by Tri-Py(+) -Me-PF. The overall change in the relative amount of unsaturated fatty acids and the formation of PE hydroxides and hydroperoxides evidence the damages in bacterial phospholipids caused by this lethal treatment.