Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells.

Abstract

Complex I ND subunits are mutational hot spots in tumor mtDNA. Genetic changes that alter Complex I structure and function may alter a cell's ability to respond to oxygen deficit and consolidate hypoxia rescue mechanisms, and may contribute to resistance to chemotherapeutic agents that require redox cycling for activation.