The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)

Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein

Nature · 1995 · 389 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +2

Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

Steven R. Meshnick, Abraham Thomas, Allen Ranz et al. · Molecular and Biochemical Parasitology · 1991 · 300 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin.

Thomas A. Dix, Lawrence J. Marnett · Journal of Biological Chemistry · 1985 · 197 citations · Full text

Life Sciences, Biochemistry, Chemistry +12

Mechanism-Based Design, Synthesis, and in vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance of a Carbon-Centered Radical for Antimalarial Activity

Gary H. Posner, Chang Ho Oh, Dasong Wang et al. · Journal of Medicinal Chemistry · 1994 · 187 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

The interaction of artemisinin with malarial hemozoin

Yu-Long Hong, Ying-Zi Yang, Steven R. Meshnick · Molecular and Biochemical Parasitology · 1994 · 179 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12